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Zuckerbraun Lab



Location

NW607 MUH

Principal Investigator

Research Description

Dr. Zuckerbraun’s laboratory focuses on two main areas of research.  The first are investigations into the protective responses within the liver that limit injury in response to hemorrhage or sepsis.  The common adaptive cellular responses to hemorrhage or sepsis are integral to limit tissue/organ injury, thus allowing patients to survive such insults. His investigations have centered on the roles of heme oxgenase/carbon monoxide (CO) cell signaling, as well as nitrite/nitric oxide (NO) cell signaling in regulating these processes.  Dr. Zuckerbraun’s published and preliminary data show that CO can help to maintain tissue viability in models of hemorrhagic shock and experimental sepsis. Dr. Zuckerbraun and collaborators have patented the use of CO as a therapeutic for hemorrhagic shock, fulminant hepatic failure, intestinal injury, and vascular injury.  A second area of laboratory investigation has been focused on vascular injury and pulmonary arterial hypertension.  These investigations have also centered on the protective roles of CO,NO, or nitrite.  Much of this work has focused on the development of therapeutics for these disease processes.

Lab Members

Publications

Nassour I, Kautza B, Rubin M, Escobar D, Luciano J, Loughran P, Gomez H, Scott J, Gallo D, Brumfield J, Otterbein LE, Zuckerbraun BS. Carbon monoxide protects against hemorrhagic shock and resuscitation-induced microcirculatory injury and tissue injury. Shock. 2015 Feb;43(2):166-71. doi:10.1097/SHK.0000000000000264. View Publication

Otterbein LE, Zuckerbraun BS (co-first author), Haga M, Liu F, Song R, Usheva A, Stachulak C, Bodyak N, Smith RN, Csizmadia E, Tyagi S, Akamatsu Y, Flavell RJ, Billiar TR, Tzeng E, Bach FH, Choi AM, Soares MP. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med. 2003 9(2):183-90. | View Publication

Zuckerbraun BS, Shapiro RA, Billiar TR, Tzeng E.  RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression.  Circulation. 2003 Aug 19;108(7):876-81. | View Publication

Zuckerbraun BS, Billiar TR, Otterbein SL, Kim PK, Liu F, Choi AM, Bach FH, Otterbein LE.  Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.  J Exp Med. 2003 Dec 1;198(11):1707-16 | View Publication

Zuckerbraun BS, McCloskey CA, Gallo D, Liu F, Ifedigbo E, Otterbein LE, Billiar TR.  Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.  Shock. 2005 Jun;23(6):527-532. | View Publication

Zuckerbraun BS, Chin BY, Weigel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S, Otterbein LE.  Carbon monoxide reverses established pulmonary hypertension.  J Exp Med.  2006 Sep 4;203(9):2109-19. | View Publication

Zuckerbraun BS, Chin BY, Bilban M, de Costa d’Avila J, Rao J, Billiar TR, Otterbein LE.  Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species.  FASEB J.  2007 Apr;21(4):1099-106. | View Publication

Zuckerbraun BS, Shiva S, Ifedigbo E, Mathier MA, Mollen KP, Rao J, Bauer PM, Choi JJW, Curtis E, Choi AMK, Gladwin MT.  Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase dependent NO generation.  Circulation. 2010 Jan 5;121(1):98-109. | View Publication

Waltz P, Carchman EH, Young AC, Rao J, Rosengart MR, Kaczorowski DJ, Zuckerbraun BS.  Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway.  Autophagy.  2011 Mar:18(3):246-54. | View Publication

Alef MJ,Vallabhaneni R, Carchman E, Morris SM, Shiva S, Wang Y, Kelley EE, Tarpey MM, Gladwin MT, Tzeng E, and Zuckerbraun BS. Nitrite-generated nitric oxide circumvents dysregulated arginine/nitric oxide synthase signaling to protect against intimal hyperplasia in sprague-dawley rats.  Journal of Clinical Investigation. 2011 Apr 1;121(4):1646-56. | View Publication

Carchman E, Loughran P, Rao J, Rosengart MR, Zuckerbraun BS. Heme oxygenase-1 mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis.  Hepatology.  2011 Jun;53(6):2053-62. | View Publication